Biological systems are complex systems that can be understood in terms of design principles. Based on this premise, I have carried out my research in these areas:
Now I am focusing on an HIV project, aiming to construct a comprehensive mathematical model of host immune response to HIV exposure. I will use the model to study the dynamics and effectiveness of the host response and develop therapeutic strategies for HIV infection
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Reversible phosphorylation subserves robust circadian rhythms by creating a switch in inactivating the positive element. Cheng Z, Liu F, Zhang XP, Wang W. Biophys J. 97(11):2867-75. (2009) |
PubMed |
Cell fate decision mediated by p53 pulses. Zhang XP, Liu F, Cheng Z, Wang W. PNAS. 106:12245-50. (2009) |
PubMed |
Robustness analysis of cellular memory in an autoactivating positive feedback system. Cheng Z, Liu F, Zhang XP, Wang W. FEBS Lett. 582:3776-82. (2008) |
PubMed |
Linking fast and slow positive feedback loops creates an optimal bistable switch in cell signaling. Zhang XP, Cheng Z, Liu F, Wang W. Phys Rev E. 76, 031924. (2007) |
PubMed |