I am an undergraduate researcher who is studying trained immunity primarily with LPS activation of macrophages and their ability to change T-Cell expression.
As a gastroenterologist and aspiring physician-scientist, I am interested in elucidating the altered immune response underlying inflammatory bowel disease.
My research interest is to explore the effects of the NF-κB pathway on inflam-aging, through an understanding of how the BM niche creates a myeloid bias within HSCs.
I concentrated primarily on developing a computational model of the molecular regulatory network that controls macrophage responses to pathogens and cytokines during my postdoctoral researching.
2020 | Outstanding Ph.D. Graduates of Beijing City, Beijing, China |
2020 | Outstanding Ph.D. Graduates of Peking University, Beijing, China |
2019 | Yixin Internet Finance Scholarship of School of Mathematical Sciences, Peking University, Beijing, China |
2017-2019 | Peking University Second Scholarship, Beijing, China |
2018 | Minglve Innovation Scholarship of School of Mathematical Sciences, Peking University, Beijing, China |
2018 | Postgraduate Special Academic Scholarship of School of Mathematical Sciences, Peking University, Beijing, China |
2017 | Postgraduate Student Second Scholarship of Center For Quantitative Biology, Peking University, Beijing, China |
2016-2017 | China Scholarship (awarded to the selected visit scholar through a rigid academia evaluation process organized by China Scholarship Council) |
[1] SHI, B. #, GUO, X. #, WANG, Y., XIONG, Y., WANG, J., HAYASHI, K.-I., LEI, J., ZHANG, L.* & JIAO, Y.* 2018. Feedback from lateral organs controls shoot apical meristem growth by modulating auxin transport. Developmental cell.
[2] GUO, X., TANG, T., DUAN, M., ZHANG, L. & GE, H. 2022. The Nonequilibrium Mechanism of Noise Enhancer synergizing with Activator in HIV Latency Reactivation. iScience.
[3] HU, Y., LI, M., LIU, H., GUO, X., WANG, X. & LI, T. 2016. City traffic forecasting using taxi GPS data: A coarse-grained cellular automata model. arXiv preprint arXiv:1612.02540.
[4] XIONG, Y.#, WU, B.#, DD, F.#, GUO, X., TIAN, C., HU, J., LÜ, S., LONG, M., ZHANG, L.* & JIAO, Y.* 2021. A crosstalk between auxin and brassinosteroid regulates leaf shape by modulating growth anisotropy. Molecular Plant.
[5] Shen, J., GUO, X., Wang, Y.* 2021. Identifying and setting the natural spaces priority based on the multi-ecosystem services capacity index. Ecological Indicators.
[6] Shen, J., Wang, Y.*, GUO, X. 2021. Identifying and Setting Linear Water Space Priorities in Co-Urbanized Area Based on Multiple Levels and Multiple Ecosystem Services. Land.#These authors contributed equally; *Corresponding authors.
My research involves studying the mechanisms of trained immunity with macrophages. I am currently researching which transcription factors lead to this training effect when macrophages are treated with beta-glucan, a popular training stimulant.
My research interests include applying classical machine learning/deep learning to model and drive explainability of multi dimensional time-series signaling trajectories (of transcription factors).
As an aspiring physician-scientist I am primarily interested in understanding how prior insults/exposures to the immune system influence the subsequent ability of the immune system to respond to new infections.