I am a junior studying Computational and Systems Biology. My research currently focuses on understanding how inflammaging affects hematopoiesis by identifying differences in differentially expressed genes with the IκB KO model.
I am an undergraduate researcher who is studying trained immunity primarily with LPS activation of macrophages and their ability to change T-Cell expression.
Sarina Lowe
TITLE: Clinical Instructor in Gastroenterology / Grad Student EMAIL: SCLowe@nullmednet.ucla.edu EDUCATION: M.D., NYU School of Medicine (2018) B.A., Biology, Swarthmore College (2014)
Biograph
As a gastroenterologist and aspiring physician-scientist, I am interested in elucidating the altered immune response underlying inflammatory bowel disease.
Awards
2022 UCLA Gastroenterology T32 Research Award
2018 Alpha Omega Alpha Honor Medical Society
2015 Howard Hughes Medical Institute Summer Fellowship
2013 Norman Meinkoth Premedical Research Fellowship
Publications
Lowe SC, Sauk JS, Limketkai BN, Kwaan MR. Declining rates of emergent surgery for inflammatory bowel disease in the era of biologic therapy. Journal of Gastrointestinal Surgery.2021.
Lowe SC, Ream J, Hudesman D, Malter L, Bosworth B, Xia Y, Zhong H, Dane B, Megibow A, Chang S. A clinical and radiographic model to predict surgery for acute small bowel obstruction in Crohn’s disease. Abdominal Radiology.2020.
Escolano A, Stiechen JM, Dosenovic P, Kulp DW, Golijanin J, Sok D, Freund NT, Gitlin AD, Oliveira T, Araki T, Lowe S, Chen ST, Heinemann J, Yao KJ, Georgeson E, Saye-Francisco KL, Gazumyan A, Burton DR, Schief W, Nussenzweig MC. Sequential immunization elicits broadly neutralizing anti-HIV-1 antibodies in Ig knock-in mice. Cell. 2016.
My research interest is to explore the effects of the NF-κB pathway on inflam-aging, through an understanding of how the BM niche creates a myeloid bias within HSCs.
Xiaolu Guo
TITLE: Postdoctoral Scholar EMAIL: xiaoluguo@nullg.ucla.edu EDUCATION: Ph.D. in Computational Mathematics, School of Mathematical Sciences, Peking University, China, 2020 B. Sc. in Computational Mathematics, School of Mathematical Sciences, Nankai University, China, 2014
Biography
I concentrated primarily on developing a computational model of the molecular regulatory network that controls macrophage responses to pathogens and cytokines during my postdoctoral researching.
Awards
2020
Outstanding Ph.D. Graduates of Beijing City, Beijing, China
2020
Outstanding Ph.D. Graduates of Peking University, Beijing, China
2019
Yixin Internet Finance Scholarship of School of Mathematical Sciences, Peking University, Beijing, China
2017-2019
Peking University Second Scholarship, Beijing, China
2018
Minglve Innovation Scholarship of School of Mathematical Sciences, Peking University, Beijing, China
2018
Postgraduate Special Academic Scholarship of School of Mathematical Sciences, Peking University, Beijing, China
2017
Postgraduate Student Second Scholarship of Center For Quantitative Biology, Peking University, Beijing, China
2016-2017
China Scholarship (awarded to the selected visit scholar through a rigid academia evaluation process organized by China Scholarship Council)
My research involves studying the mechanisms of trained immunity with macrophages. I am currently researching which transcription factors lead to this training effect when macrophages are treated with beta-glucan, a popular training stimulant.
My research interests include applying classical machine learning/deep learning to model and drive explainability of multi dimensional time-series signaling trajectories (of transcription factors).
Aleksandr Gorin
TITLE: Infectious diseases fellow physician/Post-doctoral research fellow EMAIL: agorin@nullmednet.ucla.edu EDUCATION: M.D., David Geffen School of Medicine at UCLA (2019) Ph.D., Microbiology, Immunology, and Molecular Genetics, UCLA (2017) B.S., Molecular Biology, UC San Diego (2011)
Biography
As an aspiring physician-scientist I am primarily interested in understanding how prior insults/exposures to the immune system influence the subsequent ability of the immune system to respond to new infections.
Awards
2022 nominee UCLA Internal Medicine Fellow Teaching award
2019 UCLA DGSOM Valentine Award for Excellence in Internal Medicine
2017 Conference on Retroviruses and Opportunistic Infections – New Investigator Scholar
2016 HIV Research for Prevention Research Scholar
2011 UCSD Eleanor Roosevelt College Provost’s Scholar 2011
2010 UCSD Chancellor’s Research Scholarship
2010 UCSD Tracy Parsons Scholarship for LGBT students in Science and Mathematics
Publications
Park JJ, Stafylis C, Pearce DD, Taylor J, Little SJ, Kojima N, Gorin AM, and Klausner JD. Interest, concerns, and attitudes among men who have sex with men and healthcare providers toward prophylactic use of doxycycline against Chlamydia trachomatis infections and syphilis. Sexually transmitted diseases. 2021.
Gorin AM, Du Y, Liu F, Zhang T, Ng HL, Hofmann, C, Cumberland WG, Sun R, and Yang OO. HIV-1 epitopes presented by MHC class I types associated with superior immune containment of viremia have highly constrained fitness landscapes. PLoS Pathogens. 2017.
Du Y, Zhang T, Dai L, Zheng X, Gorin AM, Oishi J, Wu T, Yoshizawa JM, Li X, Yang OO, Martinez-Masa O, Detels R, and Sun R. Effect of mutations on replicative fitness and MHC-I binding affinity are two of the determinants underlying CTL escape of HIV-1 Gag epitopes. mBio. 2017.
Homann S, Hofmann C, Gorin AM, Huynh D, Yang OO, and Kelesidis T. A Novel Rapid and Reproducible Flow Cytometric Method for Optimization of Transfection Efficiency in Cells. PLoS One. 2017.
