My research interest is to explore the effects of the NF-κB pathway on inflam-aging, through an understanding of how the BM niche creates a myeloid bias within HSCs.
Xiaolu Guo
TITLE: Postdoctoral Scholar EMAIL: xiaoluguo@nullg.ucla.edu EDUCATION: Ph.D. in Computational Mathematics, School of Mathematical Sciences, Peking University, China, 2020 B. Sc. in Computational Mathematics, School of Mathematical Sciences, Nankai University, China, 2014
Biography
I concentrated primarily on developing a computational model of the molecular regulatory network that controls macrophage responses to pathogens and cytokines during my postdoctoral researching.
Awards
2020
Outstanding Ph.D. Graduates of Beijing City, Beijing, China
2020
Outstanding Ph.D. Graduates of Peking University, Beijing, China
2019
Yixin Internet Finance Scholarship of School of Mathematical Sciences, Peking University, Beijing, China
2017-2019
Peking University Second Scholarship, Beijing, China
2018
Minglve Innovation Scholarship of School of Mathematical Sciences, Peking University, Beijing, China
2018
Postgraduate Special Academic Scholarship of School of Mathematical Sciences, Peking University, Beijing, China
2017
Postgraduate Student Second Scholarship of Center For Quantitative Biology, Peking University, Beijing, China
2016-2017
China Scholarship (awarded to the selected visit scholar through a rigid academia evaluation process organized by China Scholarship Council)
My research involves studying the mechanisms of trained immunity with macrophages. I am currently researching which transcription factors lead to this training effect when macrophages are treated with beta-glucan, a popular training stimulant.
My research interests include applying classical machine learning/deep learning to model and drive explainability of multi dimensional time-series signaling trajectories (of transcription factors).
Aleksandr Gorin
TITLE: Infectious diseases fellow physician/Post-doctoral research fellow EMAIL: agorin@nullmednet.ucla.edu EDUCATION: M.D., David Geffen School of Medicine at UCLA (2019) Ph.D., Microbiology, Immunology, and Molecular Genetics, UCLA (2017) B.S., Molecular Biology, UC San Diego (2011)
Biography
As an aspiring physician-scientist I am primarily interested in understanding how prior insults/exposures to the immune system influence the subsequent ability of the immune system to respond to new infections.
Awards
2022 nominee UCLA Internal Medicine Fellow Teaching award
2019 UCLA DGSOM Valentine Award for Excellence in Internal Medicine
2017 Conference on Retroviruses and Opportunistic Infections – New Investigator Scholar
2016 HIV Research for Prevention Research Scholar
2011 UCSD Eleanor Roosevelt College Provost’s Scholar 2011
2010 UCSD Chancellor’s Research Scholarship
2010 UCSD Tracy Parsons Scholarship for LGBT students in Science and Mathematics
Publications
Park JJ, Stafylis C, Pearce DD, Taylor J, Little SJ, Kojima N, Gorin AM, and Klausner JD. Interest, concerns, and attitudes among men who have sex with men and healthcare providers toward prophylactic use of doxycycline against Chlamydia trachomatis infections and syphilis. Sexually transmitted diseases. 2021.
Gorin AM, Du Y, Liu F, Zhang T, Ng HL, Hofmann, C, Cumberland WG, Sun R, and Yang OO. HIV-1 epitopes presented by MHC class I types associated with superior immune containment of viremia have highly constrained fitness landscapes. PLoS Pathogens. 2017.
Du Y, Zhang T, Dai L, Zheng X, Gorin AM, Oishi J, Wu T, Yoshizawa JM, Li X, Yang OO, Martinez-Masa O, Detels R, and Sun R. Effect of mutations on replicative fitness and MHC-I binding affinity are two of the determinants underlying CTL escape of HIV-1 Gag epitopes. mBio. 2017.
Homann S, Hofmann C, Gorin AM, Huynh D, Yang OO, and Kelesidis T. A Novel Rapid and Reproducible Flow Cytometric Method for Optimization of Transfection Efficiency in Cells. PLoS One. 2017.
Mark Xiang
TITLE: Graduate Student (PhD) PROGRAM: Bioinformatics (2020 – present) EMAIL: markxiang@nullg.ucla.edu EDUCATION: B.S., University of Massachusetts, Amherst (2020)
Research Interests
My current research interests are how NFκB dynamics informs B cell fate decision. Our lab has previously determined 6 informative NFκB dynamical features, but what remains unknown is whether cells actually use these information to make decisions – apoptosis, proliferation, division and/or differentiation. I focus on RelA and cRel, two distinct subunit of NFκB, to study signaling dynamics and their correlation with fate decision.
Connor Razma
TITLE: Undergraduate Student
MAJOR: Computational and Systems Biology
Biography
My research focuses on bioinformatics and data analysis. My main project involves methylation data from patients infected with cytomegalovirus post kidney transplant. I am also implementing deep learning techniques to study liver pathology images. Outside of the lab, I enjoy hiking and learning about other disciplines such as history, philosophy, and economics.
Aditya Pimplaskar
TITLE: Undergraduate Student
MAJOR: Computational and Systems Biology, concentration in Data Science
MINOR: Mathematics
Biography
My work focuses around bioinformatics and data analysis for the lab. My current research develops single cell RNA sequencing methods for reconstructing heterogeneous time course trajectories from snapshot time series data. I have previously worked on analyzing ChIP-seq and RNA-seq data, along with performing DNA motif-oriented analysis to investigate DNA-binding mechanisms of RelA. In the UCLA BIG Summer program, I used genomic landscapes in small cell lung cancer cell lines to predict drug sensitivities. Outside the lab, some of my interests include playing the piano and guitar, engaging in community service projects for science education and mentorship, playing and watching sports, trying new cuisines, and analyzing sports data.
I joined the Hoffmann lab in June 2020. I work primarily with Dr. Quen Cheng. My research focuses on analyzing RNA-seq and ChIP-seq datasets to understand the variable outcomes of immune cells upon infection. Outside of the lab, I enjoy swimming, hiking and playing the piano.”.
Jennifer Chia
TITLE: Resident Physician EMAIL: JChia@nullmednet.ucla.edu EDUCATION: Residency in Anatomic Pathology, UCLA (2018 – 2021) M.D. Weill Cornell Medicine of Cornell University, Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program (2018) Ph.D., Weill Cornell Graduate School of Cornell University, Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program (2016) B.A., University of Colorado (2007)
Biography
As a developing physician scientist and Hematopathologist-in-training, I am interested in understanding how inflammatory signaling in the bone marrow microenvironment may influence hematopoiesis and human bone marrow disorders.
Publications
Azar, S., Buen, F., Chia, J.J.,
Ma, Y., Caron, J. Dry, S. Bhuta, S. Abemayor, E. Spindle cell lipoma
arising from the supraglottis: a case report and review of the
literature. Head and Neck Pathology. [In press manuscript number
HANP-D-20-00412R1; accepted for publication 11/19/2020.]
Chia J.J.,
Zhu T., Chyou S., Dasoveanu D.C., Carballo C., Tian S., Magro C.M.,
Rodeo S., Spiera R.F., Ruddle N.H., McGraw T.E., Browning J.L., Lafyatis
R., Gordon J.K., Lu T.T. Dendritic
cells maintain adipose-derived stromal cells in skin fibrosis. J Clin
Invest. 2016 Nov 1;126(11):4331-4345. PMID: 27721238; PMCID: PMC5096920.
Dasoveanu D.C., Shipman W.D., Chia J.J.,
Chyou S., Lu T.T. Regulation of lymph node vascular-stromal compartment
by dendritic cells. Trends in immunology. 2016; 37(11):764-777.
PMID: 27638128; PMCID: PMC5492966.
Chia, J.J. & Lu, T.T. Update on macrophages and innate immunity in scleroderma. Curr Opin Rheumatol 27, 530-536
(2015). PMID: 26352734; PMCID: PMC4763869.
