TITLE: Undergraduate Student
EMAIL: jessicazhang2538@nullulca.edu
Title: PhD Student
Email: phy198@nullg.ucla.edu
Education:
Bachelor of Biomedicine, University of Melbourne
Bachelor of Science (Applied Mathematics), University of Melbourne
Master of Science (Applied Mathematics & Biomathematics), University of Melbourne
TITLE: Undergraduate Student
EMAIL: lemmonshen@nullg.ucla.edu
I’m a first-year undergraduate student studying Statistics and Data Science at UCLA. My research is mainly focused on how epigenetic and signaling mechanisms drive trained immunity.
TITLE: Undergraduate student
EMAIL: dniu0427@nullg.ucla.edu
I’m a second-year undergraduate at UCLA majoring in Molecular, Cell, and Developmental Biology. My research focuses on how monocytes and macrophages are differentially altered after exposure to immune stimuli.
TITLE: Undergraduate student
EMAIL: aidannguyen27@nullucla.edu
I am a second-year undergraduate student studying Statistics and Data Science. My research involves the analysis of scRNA-seq data to uncover critical insights into bone marrow stroma cells, utilizing various computational models with R to classify cell types and understand disease mechanisms. I love to play volleyball and boardgames in my free time!
Title: MD/PhD Student
Email: NYan@nullmednet.ucla.edu
Education:
B.S., Molecular and Cellular Biology, Johns Hopkins University (2019)
I’m an MD/PhD student primarily interested in studying how changes in macrophage signaling affect cellular functions. My clinical interests are in Psychiatry and immune dysregulation in psychiatric illness.
My research is focused on understanding the mechanisms underlying the activation of gene transcription by NFκB RelA subunit. This is done by elucidating specific attributes of RelA that contribute to its ability to activate and regulate inflammatory gene expression programs by employing a panel of RelA mutations and examining their impact on transcription. By using biochemical analysis, mathematical model-aided analysis approach, RNA and ChIP-seq analyses, we find specialized, non-overlapping functions in DNA binding and transcriptional activation in RelA. My hobbies include playing beach volleyball, badminton, baking, and volunteering for Buddhist temple events.
MIMG Warsaw Fellowship, 2017-2018
Sidney Rittenberg Award, 2015
Fortmann KT, Lewis RD, Ngo KA, Fagerlund R, Hoffmann A. 2015. “A Regulated, Ubiquitin-Independent Degron in IκBα.” Journal of Molecular Biology. PMID: 26191773
Tsui R, Kearns JD, Lynch C, Vu D, Ngo KA, Basak S, Ghosh G, Hoffmann A. 2015. “IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer.” Nature Communications. PMID: 25946967.
Almaden JV, Tsui R, Liu YC, Birnbaum H, Shokhirev MN, Ngo KA, Davis-Turak JC, Otero D, Basak S, Rickert RC, Hoffmann A. 2014. “A pathway switch directs BAFF signaling to distinct NFκB transcription factors in maturing and proliferating B cells”. Cell Reports. PMID: 25497099
birnbaumharry@nullgmail.com
Office: NSB 3209
Phone: 610-764-6695
B.A. Mathematics, University of Pennsylvania – 2012
More about the Next-Gen Gene Expression Core
Mukherjee, S.P., Behar, M., Birnbaum, H.A, Hoffmann, A., Wright, P.E., Ghosh, G.
Analysis of the RelA:CBP/p300 interaction reveals its involvement in NFkB-driven transcription
PLOS Biology, 11:e1001647
My current research interests are in developing image based assays for mammalian cell signaling systems that utilized live-cell approaches to view signaling events in real time at a single cell level to reveal events and mechanisms obscured by population averaging biochemical approaches. I am interesting in assays with workflows amenable to automation that can be used to generate functional data for the design and validation of mathematical models of gene regulatory networks.
| Citation | Link |
|---|---|
| Transient nuclear envelope rupture during interphase in human cancer cells. Nucleus 2012 | PubMed |
| Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo. JCB 2009 | PubMed |
| Type 2 intramolecular nitroso Diels-Alder reaction. Synthesis and structure of bridgehead oxazinolactams. Org. Lett. 2000 | PubMed |
In my spare time I try to stay fit doing judo 柔道 or gymnastics or playing volleyball at the beach. I also am a photography enthusiast and spend a lot of time taking random pictures of buildings or landscapes that catch my eye. I’m a Mac.
