My current research focuses on how inflammation impacts early B lymphopoiesis and upstream hematopoiesis in aging. By using quantitative muti-color flow cytometry analysis, in vivo bone marrow chimera experiments, mathematical modeling, and single-cell transcriptomic profiling, we can pin down the stage that is substantially impacted by the activation of inflammatory signaling and the discrepancy between cell-surface marker and transcriptomic profiles between developmental stages. My hobbies include film/digital photography and cooking.
Warsaw Fellowship, Jul. 2018, University of California, Los Angeles, CA, United States
Top Poster Award, Jun. 2018, Immunology, Inflammation, Infection, and Transplantation research theme retreat, David Geffen School of Medicine, University of California, Los Angeles, CA, United States
Sidney C. Rittenberg Award, Dec. 2015, University of California, Los Angeles, CA, United States
Koushik Roy, Simon Mitchell, Yi Liu, Sho Ohta, Yu-Sheng Lin, Marie Oliver Metzig, Stephen L Nutt and Alexander Hoffmann, A Regulatory Circuit Controlling the Dynamics of NFκB cRel Transitions B Cells from Proliferation to Plasma Cell Differentiation, Immunity, Immunity. 2019 Mar 19;50(3):616-628
Riku Fagerlund, Marcelo Behar, Karen T. Fortmann, Y. Eason Lin, Jesse D. Vargas, and Alexander Hoffmann, Anatomy of a negative feedback loop: the case of IκBα, J R Soc Interface. 2015 Sep 6;12(110):0262
Tsung-Feng Wu, Tony Minghung Yen, Yuanyuan Han, Yu-Jui Chiu, Eason Y.-S. Lin and Yu-Hwa Lo, A light-sheet microscope compatible with mobile devices for label-free intracellular imaging and biosensing, Lab Chip. 2014 Sep 7;14(17):3341-8