Publications(short)
Gene regulatory logic of the interferon-β enhancer is characterized by two selectively deployed modes of transcription factor synergySchiffman, A., Cheng, Z., Ourthiague D., Hoffmann, A. PNAS 2025 Modeling heterogeneous signaling dynamics of macrophages reveals principles of information transmission in stimulus responsesGuo, X., Adelaja, A., Singh, A., Wollman, R., Hoffmann, A. Nat Comm 2025 Synergy and antagonism in the integration of BCR and CD40 signals that control B-cell population expansionHuang, H., Vaidehi Narayanan, H., Xiang, M.Y., Kesarwani, K., Hoffmann, A. MSB 2025 NF-κB RelB suppresses the inflammatory gene expression programs of dendritic cells by competing with RelA for binding to target gene promotersNavarro, H.I., Daly, A.E., Rodriguez, B., Wu, S., Ngo, K.A., Fraser, A., Schiffman, A., Liu, Y., Smale, S.T., Chia, J.J., Hoffmann, A. Cell Discovery 2025 IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophagesChavaz, C., Lin, K., Malveaux, A., Gorin, A., Brizuela, S., Cheng, Q.J., Hoffmann, A. Sci Signal. 2025