Publications(short)
Stimulus-specific responses in innate immunity: Multilayered regulatory circuitsLuecke, S., Sheu, K.M., Hoffmann, A. Immunity 2021 NFκB dynamics determine the stimulus-specificity of epigenomic reprogramming in macrophageCheng, Q.J., Ohta, S., Sheu, K.M., Spreafico, R., Adelaja, A., Taylor, B., Hoffmann, A. Science 2021 Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responsesAdelaja, A., Taylor, B., Sheu, K.M., Liu, Y., Luecke, S., Hoffmann, A. Immunity 2021 Quantifying information accumulation encoded in the dynamics of biochemical signalingTang, Y., Adelaja, A., Ye, F., Deeds, E., Wollman, R., Hoffmann, A. Nature Commun 2021 An incoherent feedforward loop interprets NFκB/RelA dynamics to determine TNF-induced necroptosis decisionsMetzig, M.O., Tang, Y., Mitchell, S., Taylor, B., Foreman, R., Wollman, R., Hoffmann, A. Mol Syst Biol. 2020