TITLE: Postdoctoral Scholar
EMAIL: stefanieluecke@nullg.ucla.edu
EDUCATION:
Ph.D. in Biomedicine, Aarhus University, Denmark, 2018
M.Sc. in Infection and Immunity, Utrecht University, The Netherlands, 2014
B.Sc. in Biochemistry and Cell Biology, Jacobs University Bremen, Germany, 2012

Research Interests

I am investigating how combinatorial and temporal codes generated by the innate immune signaling network act together to determine stimulus-specific macrophage responses.

Publications

1: Luecke S*, Sheu KM*, Hoffmann A. Immune Sentinel Cells: Molecular Mechanisms for Combinatorial and Temporal Coding to Produce Stimulus-Appropriate Responses. Immunity. 2021; 54(9):1915-1932. Review. *SL and KMS contributed equally.

2: Juul-Madsen K, Troldborg A, Wittenborn TR, Axelsen MG, Zhao H, Klausen LH, Luecke S, Paludan SR, Steengaard-Pedersen K, Dong M, Møller HJ, Thiel S, Jensen H, Schuck P, Sutherland DS, Degn SE, Vorup-Jensen T. Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus. PNAS. 2021;118(30).

3: Adelaja A*, Taylor B*, Sheu KM, Liu Y, Luecke S, Hoffmann A. Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses. Immunity. 2021; 54, 916-930. *AA and BT contributed equally.

4: Chitadze, G, Lettau, M, Peters, C, Luecke S, Flueh C, Quabius ES, Synowitz M, Held-Feindt J, Kabelitz D. Erroneous expression of NKG2D on granulocytes detected by phycoerythrin-conjugated clone 149810 antibody. Cytometry. 2021; 1– 11.

5: Sheu KM*, Luecke S*, Hoffmann A. Stimulus-specificity in the responses of immune sentinel cells. Curr Opin Syst Biol. 2019; 18:53-61. Review. *KMS and SL contributed equally.

6: Sun C*, Luecke S*, Bodda C, Jønsson KL, Cai Y, Zhang BC, Jensen SB, Nordentoft I, Jensen JM, Jakobsen MR, Paludan SR. Cellular Requirements for Sensing and Elimination of Incoming HSV-1 DNA and Capsids. J Interferon Cytokine Res. 2019 Mar 11. doi: 10.1089/jir.2018.0141.  *CS and SLcontributed equally

7: Chitadze G, Flüh C, Quabius ES, Freitag-Wolf S, Peters C, Lettau M, Bhat J, Wesch D, Oberg HH, Luecke S, Janssen O, Synowitz M, Held-Feindt J, Kabelitz D. In-depth immunophenotyping of patients with glioblastoma multiforme: Impact of steroid treatment. Oncoimmunology. 2017 Aug 8;6(11):e1358839. doi: 10.1080/2162402X.2017.1358839.

8: Luecke S, Holleufer A, Christensen MH, Jønsson KL, Boni GA, Sørensen LK, Johannsen M, Jakobsen MR, Hartmann R, Paludan SR. cGAS is activated by DNA in a length-dependent manner. EMBO Rep. 2017 Oct;18(10):1707-1715. doi: 10.15252/embr.201744017.

9: Ogunjimi B, Zhang SY, Sørensen KB, Skipper KA, Carter-Timofte M, Kerner G, Luecke S, Prabakaran T, Cai Y, Meester J, Bartholomeus E, Bolar NA, Vandeweyer G, Claes C, Sillis Y, Lorenzo L, Fiorenza RA, Boucherit S, Dielman C, Heynderickx S, Elias G, Kurotova A, Auwera AV, Verstraete L, Lagae L, Verhelst H, Jansen A, Ramet J, Suls A, Smits E, Ceulemans B, Van Laer L, Plat Wilson G, Kreth J, Picard C, Von Bernuth H, Fluss J, Chabrier S, Abel L, Mortier G, Fribourg S, Mikkelsen JG, Casanova JL, Paludan SR, Mogensen TH. Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections. J Clin Invest. 2017 Sep 1;127(9):3543-3556. doi: 10.1172/JCI92280.

10: Luecke S, Paludan SR. Molecular requirements for sensing of intracellular microbial nucleic acids by the innate immune system. Cytokine. 2017 Oct; 98:4-14. doi: 10.1016/j.cyto.2016.10.003. Review.

11: Christensen MH, Jensen SB, Miettinen JJ, Luecke S, Prabakaran T, Reinert LS, Mettenleiter T, Chen ZJ, Knipe DM, Sandri-Goldin RM, Enquist LW, Hartmann R, Mogensen TH, Rice SA, Nyman TA, Matikainen S, Paludan SR. HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression. EMBO J. 2016 Jul 1;35(13):1385-99. doi: 10.15252/embj.201593458.

12: Chitadze G, Lettau M, Luecke S, Wang T, Janssen O, Fürst D, Mytilineos J, Wesch D, Oberg HH, Held-Feindt J, Kabelitz D. NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human γδ T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors. Oncoimmunology. 2015 Dec 10;5(4):e1093276.

13: Luecke S, Paludan SR. Innate recognition of alphaherpesvirus DNA. Adv Virus Res. 2015;92:63-100. doi: 10.1016/bs.aivir.2014.11.003. Review.