TITLE: Graduate Student (PhD)
PROGRAM: Bioinformatics (2020 – present)
EMAIL: markxiang@nullg.ucla.edu
EDUCATION:
B.S., University of Massachusetts, Amherst (2020)
Research Interests
My current research interests are how NFκB dynamics informs B cell fate decision. Our lab has previously determined 6 informative NFκB dynamical features, but what remains unknown is whether cells actually use these information to make decisions – apoptosis, proliferation, division and/or differentiation. I focus on RelA and cRel, two distinct subunit of NFκB, to study signaling dynamics and their correlation with fate decision.
TITLE: Undergraduate Student
MAJOR: Computational and Systems Biology
Biography
My research focuses on bioinformatics and data analysis. My main project involves methylation data from patients infected with cytomegalovirus post kidney transplant. I am also implementing deep learning techniques to study liver pathology images. Outside of the lab, I enjoy hiking and learning about other disciplines such as history, philosophy, and economics.
TITLE: Undergraduate Student
MAJOR: Computational and Systems Biology, concentration in Data Science
MINOR: Mathematics
Biography
My work focuses around bioinformatics and data analysis for the lab. My current research develops single cell RNA sequencing methods for reconstructing heterogeneous time course trajectories from snapshot time series data. I have previously worked on analyzing ChIP-seq and RNA-seq data, along with performing DNA motif-oriented analysis to investigate DNA-binding mechanisms of RelA. In the UCLA BIG Summer program, I used genomic landscapes in small cell lung cancer cell lines to predict drug sensitivities. Outside the lab, some of my interests include playing the piano and guitar, engaging in community service projects for science education and mentorship, playing and watching sports, trying new cuisines, and analyzing sports data.
TITLE: Undergraduate Student
MAJOR: Microbiology, Immunology and Molecular Genetics
MINOR: Biomedical Research, Bioinformatics
EMAIL: anhng01@nullg.ucla.edu
Biography
I joined the Hoffmann lab in June 2020. I work primarily with Dr. Quen Cheng. My research focuses on analyzing RNA-seq and ChIP-seq datasets to understand the variable outcomes of immune cells upon infection. Outside of the lab, I enjoy swimming, hiking and playing the piano.”.
TITLE: Resident Physician
EMAIL: JChia@nullmednet.ucla.edu
EDUCATION:
Residency in Anatomic Pathology, UCLA (2018 – 2021)
M.D. Weill Cornell Medicine of Cornell University, Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program (2018)
Ph.D., Weill Cornell Graduate School of Cornell University, Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program (2016)
B.A., University of Colorado (2007)
Biography
As a developing physician scientist and Hematopathologist-in-training, I am interested in understanding how inflammatory signaling in the bone marrow microenvironment may influence hematopoiesis and human bone marrow disorders.
Publications
Azar, S., Buen, F., Chia, J.J.,
Ma, Y., Caron, J. Dry, S. Bhuta, S. Abemayor, E. Spindle cell lipoma
arising from the supraglottis: a case report and review of the
literature. Head and Neck Pathology. [In press manuscript number
HANP-D-20-00412R1; accepted for publication 11/19/2020.]
Chia J.J.,
Zhu T., Chyou S., Dasoveanu D.C., Carballo C., Tian S., Magro C.M.,
Rodeo S., Spiera R.F., Ruddle N.H., McGraw T.E., Browning J.L., Lafyatis
R., Gordon J.K., Lu T.T. Dendritic
cells maintain adipose-derived stromal cells in skin fibrosis. J Clin
Invest. 2016 Nov 1;126(11):4331-4345. PMID: 27721238; PMCID: PMC5096920.
Dasoveanu D.C., Shipman W.D., Chia J.J.,
Chyou S., Lu T.T. Regulation of lymph node vascular-stromal compartment
by dendritic cells. Trends in immunology. 2016; 37(11):764-777.
PMID: 27638128; PMCID: PMC5492966.
Chia, J.J. & Lu, T.T. Update on macrophages and innate immunity in scleroderma. Curr Opin Rheumatol 27, 530-536
(2015). PMID: 26352734; PMCID: PMC4763869.
Hains, L.E., Loram, L.C., Taylor, F., Strand, K., Wieseler, J.L., Barrientos, R., Young, J.J.,
Frank, M.G., Sobesky, J., Martin, T.J., Eisenach, J.C., Maier, S.F.,
Johnson, J.D., Fleshner, M.R., & Watkins, L.R. 2011. Prior
laparotomy or corticosterone potentiates lipopolysaccharide-induced
fever and sickness behaviors. J Neuroimmunol. 2011
Oct 28;239(1-2):53-60. PMID: 21907418; PMCID: PMC3205218.
Chia, D.J., Young, J.J.,
Mertens, A.R., Rotwein, P.R. 2010. Distinct alterations in chromatin
organization of the two IGF-I promoters precede growth hormone-induced
activation of IGF-I gene transcription. Mol Endocrinol. 2010
Apr;24(4):779-89. PMID: 20160126; PMCID: PMC2852351.
Young, J.J.,
Mehdi, A., Stohl, L., Levin, L.R., Buck, J., Wagner, J.,Stessin, A.M.
2008. ‘Soluble’ adenylyl cyclase-generated cyclic AMP promotes fast
migration
in PC12 cells. J Neurosci Res. 2008 Jan;86(1):118-24. PMID: 17680672;
PMCID: PMC2587045.
Awards & Fellowships:
2019: Translational Research Fund project support, Department of Pathology, UCLA
2018: Herman L. Jacobius Prize in Pathology, Weill Cornell Medicine of Cornell University
2015: Outstanding Poster Award, Weill Cornell Graduate School of Cornell University
2014-2015: T32 funding award
to the Immunology and Microbial Pathogenesis Program of Weill Cornell
Graduate School of Cornell University
2009 – 2011: T32 to the Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program
2006 – 2007: Undergraduate Research Assistantship funding award, University of Colorado
2006: Leibowitz Fellowship Undergraduate Prize, Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program
2004 – 2007: Puksta Scholarship, University of Colorado
2004 – 2007: Norlin Scholarship, University of Colorado
